rituximab

There’s Nothing Quite Like Tooth Pain

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Last weekend, I had a Rituximab infusion aimed at keeping my vasculitis in remission. Then on Tuesday I started with pain in my lower jar and noticed that part of one of my wisdom teeth had broken away. I got an emergency Dentist appointment on Wednesday and had to have the tooth extracted.

Before the extraction and since, I’ve had pain in my lower jaw and face. There’s nothing quite like tooth pain is there? This actually reminds me what I’ve written about pain, in FINDING YOUR HAPPINESS:

Your Pain

Part of being alive is experiencing pain. There are different types of pain. Pain can be physical, mental or emotional. Any type of pain reduces your quality of life and will make you less happy.

You should address any pain promptly, to prevent it from getting worse and to promote healing.

Physical Pain
Physical pain is often managed, rather than cured or healed. Pain management can involve medications, exercises and sometimes surgery. Physical pain can be acute (coming on suddenly and is short term) or chronic (long term).

Acute physical pain is a sign that something is wrong inside your body. Chronic pain is caused by diseases and disorders inside your body. If you’re in physical pain, I highly recommend that you see your GP.

Your GP will complete an assessment, tests/investigations to work out the cause of the pain and work with you to develop a treatment plan.

A good example of physical pain is a broken leg. Imagine you fall and break your leg. You are in pain and seek medical attention. You have an x-ray that confirms the broken bone. You have surgery to repair it.
After surgery you have a period of immobilisation to allow the bone to heal and then have physiotherapy to regain muscle strength.

Within 3-6 months you are back to doing everything you used to do before the injury. Walking, running and dancing. Your leg is healed. You are healed.

Mental Pain
We don’t know enough about mental pain. Sometimes mental pain is managed, sometimes it is healed.

Mental pain is caused by mental illnesses. Sometimes mental illnesses run in families, suggesting that the cause could be genetic. Sometimes mental illnesses are caused by life events.

There are many different types of mental illnesses, some are acute and some are chronic. Examples of mental illnesses include anxiety, depression, bipolar and schizophrenia.

It can be difficult for a doctor to diagnose mental illnesses due to similar symptoms. Even Psychiatrists (doctors that specialise in mental health) have difficulty diagnosing mental illnesses.

Diagnosis of mental illnesses can take a significant amount of time. There’s no blood test or scans that can be completed to confirm whether an individual has mental illnesses or not, let alone which specific mental illness they have.

I would highly recommend that you see your GP if you are experiencing mental pain.

If you’re experiencing mental pain, don’t wait for a diagnosis. Start to manage your symptoms immediately, to the best of your ability.

In some cases people can fully recover from mental pain/illnesses. Whereas in other cases it is about long term management of symptoms.

Recovery from mental pain/illnesses doesn’t have set timescales. It usually takes months to years, depending on the individual and the circumstances. But every year many people do recover from mental pain/illnesses.

Emotional Pain
A conversation about emotional pain in western healthcare is not currently happening, but it needs to.

Symptoms of Pain
With all types of pain you will have a combination of physical, mental and emotional symptoms. Let me give you an example of this from my own life.

I once had severe stomach pains. They’d come and go, but were incredibly painful when present. I went to see my GP and had a range of tests/investigations. Everything came back normal.

However physically, my body always felt tight. Sometimes my chest felt tight, like it was difficult to breathe. At these times, my heart beat fast and I sweated excessively.

Eventually my GP diagnosed me with anxiety, a mental illness. I was prescribed medication and referred for therapy. It took several years, but I came to realise that my anxiety was often caused by my emotional state. Fear seemed to frequently trigger my anxiety.

I realised that in order to effectively treat my anxiety, I needed to address the fear. So that’s what I did.

Whatever symptoms of pain you have it is essential that you work out what it is and address the cause(s).

(From: FINDING YOUR HAPPINESS by Antony Simpson, 2026, pages 55-57.)

I’m currently on antibiotics and prescription painkillers. So I will be taking it easy this weekend.

Blog soon,

Antony

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Health Update: Vasculitis Remission, Blood Sugar Reduction (Type 1 Diabetes) and the Hole in the Roof of My Mouth

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I am pleased to announce that my vasculitis is in remission (see this page on Vasculitis UK for more information). This means that there are no active signs of the disease and my blood results show no signs of inflammation.

This is thanks to the excellent care of the Specialist Doctors in the NHS and the Rituximab infusions provided by the NHS.

All of the care I have received from NHS Staff has been nothing short of exceptional. Staff have been kind and compassionate. They have delivered safe, high quality and evidenced-based care.

The care has been driven by clinical need, without staff having to worry about the cost and without me having to worry about my ability to pay. I am beyond grateful.

My blood sugars have continued to reduce with my Hba1C currently being 52. My Hba1C was 58 in February 2025 and 99 before that. My Medtronic insulin pump (the MiniMed 780G) has played a massive role in this reduction, but so have better diet, increased exercise and loss of a bit of weight.

I have come off all medications, apart from insulin. This includes medications for high blood pressure, high cholesterol and mental health medications. I have made a number of changes to my life to become the happiest that I have ever been.

The hole in the roof of my mouth has gotten slightly bigger, now being about 1cm in size. However given the improvements to my overall health and the fact that the vasculitis is now in remission, the surgeon is keen to repair the hole in the roof of my mouth in the coming months.

That’s about it for my health update. Write soon,

Antony

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Vasculitis Treatment: Rituximab

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The Vasculitis flare ups had been getting more and more frequent. More painful. So when my blood test results can back abnormal, I can’t say that I was surprised.

In the next month, I’ll be having two infusions of Rituximab, two weeks apart.

Let’s be clear about the aim of this treatment:

It’s to try to slow down the progress of the Vasculitis. Not to treat it or cure it. Just to slow it down.

What is Rituximab?
Rituximab is a drug that essentially kills certain white blood cells that make up the immune system.

Side Effects of Rituximab Treatment Include:

  • Fatigue
  • Nausea / Vomiting
  • Gastro Issues – loose bowels or constipation
  • Rashes / Hives
  • Hair Loss
  • Headaches
  • Swelling caused by a build up of fluid
  • Allergic Reaction – causing a high temperature and potentially difficulty in breathing
  • Weight loss
  • High blood sugars
  • Anxiety / Agitation
  • Dizziness
  • Mouth Ulcers
  • Sweating

But the big one is an increased risk of getting an infection. Infections that the body would usually be able to fight off, it won’t be able to. This means that any infection could become quickly life threatening and potentially kill me (if not treated promptly or if I am just unlucky).

It’s a scary time. But whatever I think and feel about it, its got to be done.

Hopefully write soon,

Antony

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